Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer Risk
Summary: Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is well documented in Alzheimer disease (AD). Herein, we investigated neuroinflammation that emerges during mid-life aging, chronological and endocrinological, in the female b...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-12-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220310269 |
| _version_ | 1831634260819181568 |
|---|---|
| author | Aarti Mishra Yuan Shang Yiwei Wang Eliza R. Bacon Fei Yin Roberta D. Brinton |
| author_facet | Aarti Mishra Yuan Shang Yiwei Wang Eliza R. Bacon Fei Yin Roberta D. Brinton |
| author_sort | Aarti Mishra |
| collection | DOAJ |
| description | Summary: Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is well documented in Alzheimer disease (AD). Herein, we investigated neuroinflammation that emerges during mid-life aging, chronological and endocrinological, in the female brain as an early initiating mechanism driving AD risk later in life. Analyses were conducted in a translational rodent model of mid-life chronological and endocrinological aging followed by validation in transcriptomic profiles from women versus age-matched men. In the translational model, the neuroinflammatory profile of mid-life aging in females was endocrine and chronological state specific, dynamic, anatomically distributed, and persistent. Microarray dataset analyses of aging human hippocampus indicated a sex difference in neuroinflammatory profile in which women exhibited a profile comparable to the pattern discovered in our translational rodent model, whereas age-matched men exhibited a profile consistent with low neuroimmune activation. Translationally, these findings have implications for therapeutic interventions during mid-life to decrease late-onset AD risk. |
| first_indexed | 2024-12-19T05:50:56Z |
| format | Article |
| id | doaj.art-aedff3e8737c47e9b21f52d74cee8ec1 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-19T05:50:56Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-aedff3e8737c47e9b21f52d74cee8ec12022-12-21T20:33:38ZengElsevieriScience2589-00422020-12-012312101829Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer RiskAarti Mishra0Yuan Shang1Yiwei Wang2Eliza R. Bacon3Fei Yin4Roberta D. Brinton5Center for Innovation in Brain Science, University of Arizona, Tucson, AZ 85719, USACenter for Innovation in Brain Science, University of Arizona, Tucson, AZ 85719, USACenter for Innovation in Brain Science, University of Arizona, Tucson, AZ 85719, USADepartment of Medical Oncology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USACenter for Innovation in Brain Science, University of Arizona, Tucson, AZ 85719, USACenter for Innovation in Brain Science, University of Arizona, Tucson, AZ 85719, USA; Corresponding authorSummary: Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is well documented in Alzheimer disease (AD). Herein, we investigated neuroinflammation that emerges during mid-life aging, chronological and endocrinological, in the female brain as an early initiating mechanism driving AD risk later in life. Analyses were conducted in a translational rodent model of mid-life chronological and endocrinological aging followed by validation in transcriptomic profiles from women versus age-matched men. In the translational model, the neuroinflammatory profile of mid-life aging in females was endocrine and chronological state specific, dynamic, anatomically distributed, and persistent. Microarray dataset analyses of aging human hippocampus indicated a sex difference in neuroinflammatory profile in which women exhibited a profile comparable to the pattern discovered in our translational rodent model, whereas age-matched men exhibited a profile consistent with low neuroimmune activation. Translationally, these findings have implications for therapeutic interventions during mid-life to decrease late-onset AD risk.http://www.sciencedirect.com/science/article/pii/S2589004220310269NeuroscienceImmunologyEndocrinologyTranscriptomics |
| spellingShingle | Aarti Mishra Yuan Shang Yiwei Wang Eliza R. Bacon Fei Yin Roberta D. Brinton Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer Risk iScience Neuroscience Immunology Endocrinology Transcriptomics |
| title | Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer Risk |
| title_full | Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer Risk |
| title_fullStr | Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer Risk |
| title_full_unstemmed | Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer Risk |
| title_short | Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer Risk |
| title_sort | dynamic neuroimmune profile during mid life aging in the female brain and implications for alzheimer risk |
| topic | Neuroscience Immunology Endocrinology Transcriptomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220310269 |
| work_keys_str_mv | AT aartimishra dynamicneuroimmuneprofileduringmidlifeaginginthefemalebrainandimplicationsforalzheimerrisk AT yuanshang dynamicneuroimmuneprofileduringmidlifeaginginthefemalebrainandimplicationsforalzheimerrisk AT yiweiwang dynamicneuroimmuneprofileduringmidlifeaginginthefemalebrainandimplicationsforalzheimerrisk AT elizarbacon dynamicneuroimmuneprofileduringmidlifeaginginthefemalebrainandimplicationsforalzheimerrisk AT feiyin dynamicneuroimmuneprofileduringmidlifeaginginthefemalebrainandimplicationsforalzheimerrisk AT robertadbrinton dynamicneuroimmuneprofileduringmidlifeaginginthefemalebrainandimplicationsforalzheimerrisk |