Enhanced Immunogenicity of Inactivated Dengue Vaccines by Novel Polysaccharide-Based Adjuvants in Mice

Dengue fever, caused by any of four dengue viruses (DENV1-4), is a major global burden. Currently, there is no effective vaccine that prevents infection in dengue naïve populations. We tested the ability of two novel adjuvants (Advax-PEI and Advax-2), using aluminum hydroxide (alum) as control, to e...

Full description

Bibliographic Details
Main Authors: Shuenn-Jue Wu, Dan Ewing, Appavu K. Sundaram, Hua-Wei Chen, Zhaodong Liang, Ying Cheng, Vihasi Jani, Peifang Sun, Gregory D. Gromowski, Rafael A. De La Barrera, Megan A. Schilling, Nikolai Petrovsky, Kevin R. Porter, Maya Williams
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Microorganisms
Subjects:
Online Access:https://www.mdpi.com/2076-2607/10/5/1034