Enhanced Immunogenicity of Inactivated Dengue Vaccines by Novel Polysaccharide-Based Adjuvants in Mice

Enhanced Immunogenicity of Inactivated Dengue Vaccines by Novel Polysaccharide-Based Adjuvants in Mice

Dengue fever, caused by any of four dengue viruses (DENV1-4), is a major global burden. Currently, there is no effective vaccine that prevents infection in dengue naïve populations. We tested the ability of two novel adjuvants (Advax-PEI and Advax-2), using aluminum hydroxide (alum) as control, to e...

Full description

Bibliographic Details
Main Authors:	Shuenn-Jue Wu, Dan Ewing, Appavu K. Sundaram, Hua-Wei Chen, Zhaodong Liang, Ying Cheng, Vihasi Jani, Peifang Sun, Gregory D. Gromowski, Rafael A. De La Barrera, Megan A. Schilling, Nikolai Petrovsky, Kevin R. Porter, Maya Williams
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	Microorganisms
Subjects:	dengue virus formalin inactivation psoralen inactivation dengue vaccine polysaccharide-based adjuvants Advax™ adjuvants
Online Access:	https://www.mdpi.com/2076-2607/10/5/1034

Similar Items

Advax-CpG Adjuvant Provides Antigen Dose-Sparing and Enhanced Immunogenicity for Inactivated Poliomyelitis Virus Vaccines
by: Yoshikazu Honda-Okubo, et al.
Published: (2021-04-01)

Whole inactivated dengue virus-loaded trimethyl chitosan nanoparticle-based vaccine: immunogenic properties in ex vivo and in vivo models
by: Tuksin Jearanaiwitayakul, et al.
Published: (2021-08-01)

Immunogenicity of Adjuvanted Psoralen-Inactivated SARS-CoV-2 Vaccines and SARS-CoV-2 Spike Protein DNA Vaccines in BALB/c Mice
by: Appavu K. Sundaram, et al.
Published: (2021-05-01)

Advax4 delta inulin combination adjuvant together with ECMX, a fusion construct of four protective mTB antigens, induces a potent Th1 immune response and protects mice against Mycobacterium tuberculosis infection
by: Bruno de Paula Oliveira Santos, et al.
Published: (2017-12-01)

COMPARATIVE IMMUNOGENICITY STUDIES OF ADJUVANTS FROM VARIOUS SOURCES AND WITH DIFFERENT MECHANISMS OF ACTION FOR INACTIVATED INFLUENZA VACCINES
by: M. I Chernikova, et al.
Published: (2015-12-01)

Novel Inactivated Subtype B Avian Metapneumovirus Vaccine Induced Humoral and Cellular Immune Responses
by: Yuanling Bao, et al.
Published: (2020-12-01)

Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine
by: Yoshikazu Honda-Okubo, et al.
Published: (2017-06-01)

Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan
by: Kiwako Yamamoto-Hanada, et al.
Published: (2020-07-01)

Alanine Substitution Inactivates Cross-Reacting Epitopes in Dengue Virus Recombinant Envelope Proteins
by: Viviana C. Zomosa-Signoret, et al.
Published: (2020-02-01)

Safety and immunogenicity of inactivated Rift Valley Fever Smithburn viral vaccine in sheep
by: Matome Selina Matsiela, et al.
Published: (2023-10-01)

Comparing the Immunogenicity and Protective Effects of Three MERS-CoV Inactivation Methods in Mice
by: Nayoung Kim, et al.
Published: (2022-10-01)

The Immunogenicity and Properties of a Whole-Cell ETEC Vaccine Inactivated with Psoralen and UVA Light in Comparison to Formalin
by: Marlena M. Westcott, et al.
Published: (2023-08-01)

The Immunogenicity of CpG, MF59-like, and Alum Adjuvant Delta Strain Inactivated SARS-CoV-2 Vaccines in Mice
by: Kangwei Xu, et al.
Published: (2024-01-01)

Cell Culture-Derived Tilapia Lake Virus-Inactivated Vaccine Containing Montanide Adjuvant Provides High Protection against Viral Challenge for Tilapia
by: Weiwei Zeng, et al.
Published: (2021-01-01)

Evaluation of Two Adjuvant Formulations for an Inactivated Yellow Fever 17DD Vaccine Candidate in Mice
by: Ana Carolina dos Reis Albuquerque Cajaraville, et al.
Published: (2022-12-01)

A tetravalent dengue nanoparticle stimulates antibody production in mice
by: Silva Elisângela F, et al.
Published: (2012-03-01)

Development of a Safe and Highly Efficient Inactivated Vaccine Candidate against Lumpy Skin Disease Virus
by: Janika Wolff, et al.
Published: (2020-12-01)

Green Tea Catechin-Inactivated Viral Vaccine Platform
by: Yun H. Lee, et al.
Published: (2017-12-01)

Improved safety profile of inactivated Neethling strain of the Lumpy Skin Disease Vaccine
by: Matome Selina Matsiela, et al.
Published: (2022-12-01)

Formalin Inactivation of Virus for Safe Downstream Processing of Routine Stool Parasite Examination during the COVID-19 Pandemic
by: Pisith Chinabut, et al.
Published: (2023-01-01)

Interleukin-2 shows high adjuvanticity for an inactivated vaccine against duck Tembusu virus disease
by: Xintao Gao, et al.
Published: (2020-12-01)

A PRELIMINARY STUDY ON THE EFFECT OF INACTIVATED POLYVALENT MASTITIS VACCINES ON MILK QUANTITY AND QUALITY IN DAIRY BUFFALOES
by: M. ATHAR, G. MUHAMMAD, A. SHAKOOR, M. SAQIB, R. AHMAD1 AND A. NAUREEN
Published: (2007-04-01)

Tetracycline-Inactivating Enzymes
by: Jana L. Markley, et al.
Published: (2018-05-01)

Comparison of White Spot Syndrome Virus Inactivation by Electron Irradiation and Formalin Treatment
by: F motamedi-Sadeh, et al.
Published: (2017-08-01)

Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8+T-regulatory cells that suppress SIV positive CD4+cell activation and prevent SIV infection in the macaque model.
by: Jean Marie eAndrieu, et al.
Published: (2014-06-01)

Inactivation and Elimination of SARS-CoV-2 in Biosamples Using Simple Fixatives and Ultrafiltration
by: Ranjeet Kumar, et al.
Published: (2021-02-01)

Whole-Inactivated Influenza Virus Is a Potent Adjuvant for Influenza Peptides Containing CD8+ T Cell Epitopes
by: Peter C. Soema, et al.
Published: (2018-03-01)

Approaches of dengue control: vaccine strategies and future aspects
by: Runa Akter, et al.
Published: (2024-02-01)

Sonophotodynamic Inactivation: The power of light and ultrasound in the battle against microorganisms
by: Fernanda Alves, et al.
Published: (2021-09-01)

Vaccination With a Gamma Irradiation-Inactivated African Swine Fever Virus Is Safe But Does Not Protect Against a Challenge
by: Jutta Pikalo, et al.
Published: (2022-04-01)

Mx bio adjuvant for enhancing immune responses against influenza virus
by: Sina Soleimani, et al.
Published: (2015-06-01)

Evaluation of the Effects of Chitosan on Immune Responses due to Infectious Bursal Disease Virus (IBDV) Vaccine in Chicken
by: Sadi Armandei, et al.
Published: (2019-12-01)

Assessment of dengue virus inactivation in random donor platelets using amotosalen and ultraviolet A illumination
by: Ankit Kumar, et al.
Published: (2022-01-01)

Long-Term Protection Elicited by an Inactivated Vaccine Supplemented with a Water-Based Adjuvant against Infectious Hematopoietic Necrosis Virus in Rainbow Trout (Oncorhynchus mykiss)
by: Yujie Lin, et al.
Published: (2022-12-01)

Improvement of the inactivated SARS-CoV-2 vaccine potency through formulation in alum/naloxone adjuvant; Robust T cell and anti-RBD IgG responses
by: Melika Haghighi, et al.
Published: (2022-05-01)

Protective Efficacy of H9N2 Avian Influenza Vaccines Inactivated by Ionizing Radiation Methods Administered by the Parenteral or Mucosal Routes
by: Alessio Bortolami, et al.
Published: (2022-07-01)

Voltage sensor inactivation in potassium channels
by: Robert eBähring, et al.
Published: (2012-05-01)

An Advax-Adjuvanted Inactivated Cell-Culture Derived Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-Flavivirus Antibodies, Robust Cellular Immunity and Provides Single Dose Protection
by: Tomoyoshi Komiya, et al.
Published: (2021-10-01)

Bestatin, A Pluripotent Immunomodulatory Small Molecule, Drives Robust and Long-Lasting Immune Responses as an Adjuvant in Viral Vaccines
by: Hyeong Won Kim, et al.
Published: (2023-11-01)

Non-Thermal Plasma as a Novel Strategy for Treating or Preventing Viral Infection and Associated Disease
by: Hager Mohamed, et al.
Published: (2021-06-01)