Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice

Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice

Abstract Calcineurin (Cn), a phosphatase important for synaptic plasticity and neuronal development, has been implicated in the etiology and pathophysiology of neuropsychiatric disorders, including schizophrenia, intellectual disability, autism spectrum disorders, epilepsy, and Alzheimer’s disease....

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Bibliographic Details
Main Authors: Hideo Hagihara, Hirotaka Shoji, Mahomi Kuroiwa, Isabella A. Graef, Gerald R. Crabtree, Akinori Nishi, Tsuyoshi Miyakawa
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Brain
Subjects:
Calcineurin
Immature dentate gyrus
Dopamine receptor
cAMP
Intellectual disability
Mouse model
Online Access:https://doi.org/10.1186/s13041-022-00981-0

Internet

https://doi.org/10.1186/s13041-022-00981-0

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