Organoids Are Limited in Modeling the Colon Adenoma–Carcinoma Sequence

Organoids Are Limited in Modeling the Colon Adenoma–Carcinoma Sequence

The colon adenoma–carcinoma sequence is a multistep genomic-altering process that occurs during colorectal cancer (CRC) carcinogenesis. Organoids are now commonly used to model both non-cancerous and cancerous tissue. This study aims to investigate how well organoids mimic tissues in the adenoma–car...

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Bibliographic Details
Main Authors: Yoshihisa Tokumaru, Masanori Oshi, Ankit Patel, Wanqing Tian, Li Yan, Nobuhisa Matsuhashi, Manabu Futamura, Kazuhiro Yoshida, Kazuaki Takabe
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
organoid
colorectal cancer
adenoma–carcinoma sequence
tumor microenvironment
GSEA
xCell
Online Access:https://www.mdpi.com/2073-4409/10/3/488

Internet

https://www.mdpi.com/2073-4409/10/3/488

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