Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency

Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency

Abstract Background Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder most commonly secondary to a single mutation in the SERPINA1 gene (PI*Z) that causes misfolding and accumulation of alpha-1 antitrypsin (AAT) in hepatocytes and mononuclear phagocytes which reduces plasma AAT and creates...

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Bibliographic Details
Main Authors: Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E. Lascano, Xiao Qiang, Jesse R. West, L. Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi, Mark Brantly
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Respiratory Research
Subjects:
Alpha-1 antitrypsin
Macrophages
Extracellular vesicles
Cigarette smoke
Lung disease
Online Access:https://doi.org/10.1186/s12931-022-02161-z

Internet

https://doi.org/10.1186/s12931-022-02161-z

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