Efficient Synthesis of Acylated, Dialkyl α-Hydroxy-Benzylphosphonates and Their Anticancer Activity

Efficient Synthesis of Acylated, Dialkyl α-Hydroxy-Benzylphosphonates and Their Anticancer Activity

An efficient method applying acyl chlorides as reagents was developed for the acylation of the hindered hydroxy group of dialkyl α-hydroxy-benzylphosphonates. The procedure did not require any catalyst. A few acylations were also performed with the <i>S</i><sub>C</sub>-enanti...

Full description

Bibliographic Details
Main Authors: Petra R. Varga, Alexandra Belovics, Péter Bagi, Szilárd Tóth, Gergely Szakács, Szilvia Bősze, Rita Szabó, László Drahos, György Keglevich
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
α-hydroxyphosphonates
acylation
triethylamine
cytotoxic activity
anticancer
collateral sensitivity
Online Access:https://www.mdpi.com/1420-3049/27/7/2067

Internet

https://www.mdpi.com/1420-3049/27/7/2067

Similar Items