Effects of Sponge-Derived Alkaloids on Activities of the Bacterial α-<span style="font-variant: small-caps">D-</span>Galactosidase and Human Cancer Cell α-N-Acetylgalactosaminidase

Effects of Sponge-Derived Alkaloids on Activities of the Bacterial α-<span style="font-variant: small-caps">D-</span>Galactosidase and Human Cancer Cell α-N-Acetylgalactosaminidase

During a search for glycosidase inhibitors among marine natural products, we applied an integrated in vitro and in silico approach to evaluate the potency of some aaptamines and makaluvamines isolated from marine sponges on the hydrolyzing activity of α-N-acetylgalactosaminidase (α-NaGalase) from hu...

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Bibliographic Details
Main Authors: Natalia Utkina, Galina Likhatskaya, Olesya Malyarenko, Svetlana Ermakova, Larisa Balabanova, Lubov Slepchenko, Irina Bakunina
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomedicines
Subjects:
marine sponges
aaptamines
makaluvamines
slow-binding irreversible inhibitors
bacterial α-D-galactosidase
cancer α-N-acetylgalactosaminidase
Online Access:https://www.mdpi.com/2227-9059/9/5/510

Internet

https://www.mdpi.com/2227-9059/9/5/510

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