SAX-HPLC and HSQC NMR Spectroscopy: Orthogonal Methods for Characterizing Heparin Batches Composition

SAX-HPLC and HSQC NMR Spectroscopy: Orthogonal Methods for Characterizing Heparin Batches Composition

Heparin is a complex mixture of heterogeneous sulfated polysaccharidic chains. Its physico-chemical characterization is based on the contribution of several methods, but advantages of the use of complementary techniques have not been fully investigated yet. Strong-Anion-Exchange HPLC after enzymatic...

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Bibliographic Details
Main Authors: Franco Spelta, Lino Liverani, Alessandra Peluso, Maria Marinozzi, Elena Urso, Marco Guerrini, Annamaria Naggi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Medicine
Subjects:
heparin
characterization
composition
building blocks
SAX-HPLC
quantitative NMR
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00078/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2019.00078/full

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