Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma

Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma

Abstract Histiocytic sarcoma (HS) is an incurable aggressive tumor, and no consensus has been made on the treatment due to its rare occurrence. Since dogs spontaneously develop the disease and several cell lines are available, they have been advocated as translational animal models. In the present s...

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Main Authors: Hajime Asada, Akiyoshi Tani, Hiroki Sakuma, Miyuki Hirabayashi, Yuki Matsumoto, Kei Watanabe, Masaya Tsuboi, Shino Yoshida, Kei Harada, Takao Uchikai, Yuko Goto-Koshino, James K. Chambers, Genki Ishihara, Tetsuya Kobayashi, Mitsuhiro Irie, Kazuyuki Uchida, Koichi Ohno, Makoto Bonkobara, Hajime Tsujimoto, Hirotaka Tomiyasu
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35813-1

Internet

https://doi.org/10.1038/s41598-023-35813-1

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