Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma

Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma

Translocations involving the immunoglobulin heavy chain (IGH) locus are common abnormalities in B-lymphoblastic leukemia/lymphoma (B-ALL) and multiple myeloma. These rearrangements result in a juxtaposition of IGH enhancers to the vicinity of oncogenes, such as MYC and CRLF2, leading to the upregula...

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Bibliographic Details
Main Authors: Yanglan Fang, Man Wang, Shuhong Hu, Tanzhen Wang, Yujie Liu, Jinyan Xiao, Yiming Cai, Ying Wang, Huiying Qiu, Xiaowen Tang, Suning Chen, Depei Wu, Yang Xu, Tianhui Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
translocation
fusion gene
B-lymphoblastic leukemia/lymphoma
P2RY8
IGH
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.896858/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.896858/full

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