GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses

GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses

G-protein coupled receptors (GPCR) regulate 3’,5’-cyclic adenosine monophosphate (cAMP) levels in T cells. cAMP as ubiquitous second messenger is crucial for adequate physiology of T cells by mediating effector T cell (Teff) function as well as regulatory T cell (Treg)-mediated immunosuppression. Se...

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Bibliographic Details
Main Authors: Paula F. Krieg, Jana K. Sonner, Roberta Kurelic, Jan Broder Engler, Marlena F. Scharenberg, Simone Bauer, Viacheslav O. Nikolaev, Manuel A. Friese
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
cAMP
experimental autoimmune encephalomyelitis
FRET
GPCR
multiple sclerosis
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1113348/full

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