A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity

A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity

AimSelective chemogenetic modulation of locus coeruleus (LC) neurons would allow dedicated investigation of the role of the LC-NA pathway in brain excitability and disorders such as epilepsy. This study investigated the feasibility of an experimental set-up where chemogenetic modification of the bra...

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Bibliographic Details
Main Authors: Latoya Stevens, Kristl Vonck, Lars Emil Larsen, Wouter Van Lysebettens, Charlotte Germonpré, Veerle Baekelandt, Chris Van den Haute, Evelien Carrette, Wytse Jan Wadman, Paul Boon, Robrecht Raedt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Neuroscience
Subjects:
locus coeruleus
chemogenetics
designer receptor exclusively activated by designer drugs
unit recording
clozapine
vagus nerve stimulation
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00162/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00162/full

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