Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment

Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment

We have observed a drug-tolerant/persister state in a human glioblastoma (GBM) cell line after exposure to temozolomide, the standard-of-care chemotherapeutic agent for GBM. We used a multicolor lentiviral genetic barcode labeling to follow cell population evolution during temozolomide treatment. We...

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Bibliographic Details
Main Authors: Marion Rabé, Lucie Fonteneau, Lisa Oliver, Alvaro Morales-Molina, Camille Jubelin, Javier Garcia-Castro, Dominique Heymann, Catherine Gratas, François M. Vallette
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glioma
persisters
clones
resistance
barcoding
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.835273/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.835273/full

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