Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals

Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals

Most genetic studies of disease have been done in European ancestry cohorts, and the relevance to other populations is not guaranteed. Here, the authors use data from 22,000 British South Asian individuals and find that the transferability of polygenic scores was high for lipids and blood pressure,...

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Bibliographic Details
Main Authors: Qin Qin Huang, Neneh Sallah, Diana Dunca, Bhavi Trivedi, Karen A. Hunt, Sam Hodgson, Samuel A. Lambert, Elena Arciero, John Wright, Chris Griffiths, Richard C. Trembath, Harry Hemingway, Michael Inouye, Sarah Finer, David A. van Heel, R. Thomas Lumbers, Hilary C. Martin, Karoline Kuchenbaecker
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32095-5

Internet

https://doi.org/10.1038/s41467-022-32095-5

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