Cyclophilin A/CD147 signaling induces the epithelial-to-mesenchymal transition and renal fibrosis in chronic allograft dysfunction by regulating p38 MAPK signaling

Cyclophilin A/CD147 signaling induces the epithelial-to-mesenchymal transition and renal fibrosis in chronic allograft dysfunction by regulating p38 MAPK signaling

Objective Our study was designed to explore the role of Cyclophilin A (CyPA)/CD147 signaling in renal allograft fibrosis and chronic allograft dysfunction (CAD).Materials and methods A rat renal transplant model with significant CAD was successfully achieved. Renal allograft tissues and blood sample...

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Bibliographic Details
Main Authors: Xuzhong Liu, Zhiwang Tang, Xi Jiang, Tianwei Wang, Lun Zhao, Zongyuan Xu, Kun Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Renal Failure
Subjects:
Cyclophilin A
CD147
epithelial-to-mesenchymal transition
kidney transplantation
chronic allograft dysfunction
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2022.2126788

Internet

https://www.tandfonline.com/doi/10.1080/0886022X.2022.2126788

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