Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies.

Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies.

During HIV-1 infection coreceptor switch from CCR5- (R5)- to CXCR4 (X4)-using viruses is associated with disease progression. X4 strains of HIV-1 are highly cytopathic to immature thymocytes. Virtually no studies have evaluated the HIV-1 quasispecies present in vivo within thymic and lymphoid tissue...

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Bibliographic Details
Main Authors: Marco Salemi, Brant R Burkhardt, Rebecca R Gray, Guity Ghaffari, John W Sleasman, Maureen M Goodenow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1978532?pdf=render

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http://europepmc.org/articles/PMC1978532?pdf=render

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