Micropatterned Neurovascular Interface to Mimic the Blood–Brain Barrier’s Neurophysiology and Micromechanical Function: A BBB-on-CHIP Model

Micropatterned Neurovascular Interface to Mimic the Blood–Brain Barrier’s Neurophysiology and Micromechanical Function: A BBB-on-CHIP Model

A hybrid blood–brain barrier (BBB)-on-chip cell culture device is proposed in this study by integrating microcontact printing and perfusion co-culture to facilitate the study of BBB function under high biological fidelity. This is achieved by crosslinking brain extracellular matrix (ECM) proteins to...

Full description

Bibliographic Details
Main Authors: Ajay Vikram Singh, Vaisali Chandrasekar, Peter Laux, Andreas Luch, Sarada Prasad Dakua, Paolo Zamboni, Amruta Shelar, Yin Yang, Vaibhav Pandit, Veronica Tisato, Donato Gemmati
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
blood–brain barrier
micropatterning
astrocyte
neuropathology
calcium signaling
Online Access:https://www.mdpi.com/2073-4409/11/18/2801

Internet

https://www.mdpi.com/2073-4409/11/18/2801

Similar Items