Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice

Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice

Inhalational exposure to crystalline silica is linked to several debilitating systemic autoimmune diseases characterized by a prominent humoral immune component, but the mechanisms by which silica induces autoantibodies is poorly understood. To better understand how silica lung exposure breaks B cel...

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Bibliographic Details
Main Authors: Mary H. Foster, Jeffrey R. Ord, Emma J. Zhao, Anastasiya Birukova, Lanette Fee, Francesca M. Korte, Yohannes G. Asfaw, Victor L. Roggli, Andrew J. Ghio, Robert M. Tighe, Amy G. Clark
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
silica
humoral autoimmunity
B cell tolerance
lupus
autoantibody transgene
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02336/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02336/full

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