Neuronal tissue-specific ribonucleoprotein complex formation on SOD1 mRNA: Alterations by ALS SOD1 mutations

Neuronal tissue-specific ribonucleoprotein complex formation on SOD1 mRNA: Alterations by ALS SOD1 mutations

Amyotrophic lateral sclerosis (ALS) is a fatal disease of unknown etiology. Mutations in copper/zinc superoxide dismutase (SOD1) are the most commonly associated genetic abnormality. Given that SOD1 is ubiquitously expressed, the exclusive vulnerability of motor neurons is one of the most puzzling i...

Full description

Bibliographic Details
Main Authors: Wei-wen Ge, Cheryl Leystra-Lantz, Teresa R. Sanelli, Jesse McLean, Weiyan Wen, Wendy Strong, Michael J. Strong
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis (ALS)
Copper/Zinc superoxide dismutase (SOD1)
Ribonucleoprotein complex
Mutations
Tissue specificity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000726

Internet

http://www.sciencedirect.com/science/article/pii/S0969996106000726

Similar Items