Diels–Alder Adducts of Morphinan-6,8-Dienes and Their Transformations

Diels–Alder Adducts of Morphinan-6,8-Dienes and Their Transformations

6,14-ethenomorphinans are semisynthetic opiate derivatives containing an ethylene bridge between positions 6 and 14 in ring-C of the morphine skeleton that imparts a rigid molecular structure. These compounds represent an important family of opioid receptor ligands in which the 6,14-etheno bridged s...

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Bibliographic Details
Main Authors: János Marton, Anikó Fekete, Paul Cumming, Sándor Hosztafi, Pál Mikecz, Gjermund Henriksen
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
morphine alkaloids
opioid receptors
morphinan-6,8-dienes
Diels–Alder reaction
Grignard addition
<i>O</i>-demethylation
Online Access:https://www.mdpi.com/1420-3049/27/9/2863

Internet

https://www.mdpi.com/1420-3049/27/9/2863

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