Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into Cells

Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into Cells

ABSTRACT Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 have a single envelope glycoprotein (S protein) that binds to human angiotensin-converting enzyme 2 (ACE2) on the host cell membrane. Previous mutational scanning studies have suggested that some substitutions correspon...

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Bibliographic Details
Main Authors: Takanari Hattori, Takeshi Saito, Kosuke Okuya, Yuji Takahashi, Hiroko Miyamoto, Masahiro Kajihara, Manabu Igarashi, Ayato Takada
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
ACE2
polymorphism
SNPs
SNVs
SARS-CoV-2
SARS-CoV
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00870-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00870-22

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