Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms

Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms

Background/AimsEnterochromaffin cells (EC cells) constitute the largest population of enteroendocrine cells and release serotonin (5-HT) in response to mechanical and chemical cues of the gastrointestinal tract (GIT). How EC cells respond to altered microbiota such as due to antibiotic treatments re...

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Bibliographic Details
Main Authors: Cuihong Zhu, Huashan Gong, Ping Luo, Li Dong, Guohua Zhang, Xueyin Shi, Weifang Rong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Physiology
Subjects:
intestinal microflora
enterochromaffin cells
hyperpolarization-activated cyclic nucleotide-gated channels 2
tryptophan hydroxylase 1
serotonin
antibiotics
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.605982/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.605982/full

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