Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms

Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms

Background/AimsEnterochromaffin cells (EC cells) constitute the largest population of enteroendocrine cells and release serotonin (5-HT) in response to mechanical and chemical cues of the gastrointestinal tract (GIT). How EC cells respond to altered microbiota such as due to antibiotic treatments re...

Full description

Bibliographic Details
Main Authors:	Cuihong Zhu, Huashan Gong, Ping Luo, Li Dong, Guohua Zhang, Xueyin Shi, Weifang Rong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-12-01
Series:	Frontiers in Physiology
Subjects:	intestinal microflora enterochromaffin cells hyperpolarization-activated cyclic nucleotide-gated channels 2 tryptophan hydroxylase 1 serotonin antibiotics
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2020.605982/full

Similar Items

Heat-killed Lactobacillus casei subsp. casei 327 promotes colonic serotonin synthesis in mice
by: Takashi Hara, et al.
Published: (2018-08-01)

Autocrine and paracrine regulatory functions of platelet serotonin
by: Elmina Mammadova-Bach, et al.
Published: (2018-08-01)

Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex
by: Gary C. Mouradian Jr., et al.
Published: (2021-07-01)

Seasonal Affective Disorder and Serotonin-Related Polymorphisms
by: C. Johansson, et al.
Published: (2001-04-01)

Examination of the mechanism of Piezo ion channel in 5-HT synthesis in the enterochromaffin cell and its association with gut motility
by: Zhenya Zhu, et al.
Published: (2023-11-01)

Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats
by: Lijuan Yu, et al.
Published: (2023-01-01)

Serotonin immunoreactive cells in extrahepatic bile ducts, major duodenal papilla and gallbladder in the domestic pig
by: Ivaylo Stefanov
Published: (2024-03-01)

The Absence of Serotonin in the Brain Alters Acute Stress Responsiveness by Interfering With the Genomic Function of the Glucocorticoid Receptors
by: Giulia Sbrini, et al.
Published: (2020-06-01)

Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population
by: Xu Fu, MD, et al.
Published: (2020-06-01)

Serotonin in the Pathogenesis of Lymphocytic Colitis
by: Cezary Chojnacki, et al.
Published: (2021-01-01)

Age-Related Alterations in the Level and Metabolism of Serotonin in the Brain of Males and Females of Annual Turquoise Killifish (<i>Nothobranchius furzeri</i>)
by: Valentina S. Evsiukova, et al.
Published: (2023-02-01)

Gastric mucosal protection by aegle marmelos against gastric mucosal damage: Role of enterochromaffin cell and serotonin
by: Purnima Singh, et al.
Published: (2015-01-01)

Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats
by: Giulia Sbrini, et al.
Published: (2022-04-01)

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy
by: Minyoung Shin, et al.
Published: (2008-10-01)

Serotonin and Melatonin in Human Lower Gastrointestinal Tract
by: Rosa Vaccaro, et al.
Published: (2023-01-01)

A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2)
by: Howard M. Lazarus, et al.
Published: (2022-04-01)

Morphological changes in serotoninergic neurites in the striatum and globus pallidus in levodopa primed MPTP treated common marmosets with dyskinesia
by: Bai-Yun Zeng, et al.
Published: (2010-12-01)

Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current
by: Zhang T, et al.
Published: (2024-04-01)

Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity
by: Job Baffin Kola, et al.
Published: (2023-05-01)

How intrauterine growth restriction due to nutritional stress changes the function of key proteins in brain serotonin metabolism during development
by: Jorge Hernández-Rodríguez, et al.
Published: (2021-01-01)

Indolamine accumulation and TDC/T5H expression profiles reveal the complex and dynamic regulation of serotonin biosynthesis in tomato (Solanum lycopersicum L.)
by: Mauro Commisso, et al.
Published: (2022-08-01)

Refining the Role of 5-HT in Postnatal Development of Brain Circuits
by: Anne Teissier, et al.
Published: (2017-05-01)

5-Hydroxytryptamine Enhances the Pacemaker Activity of Interstitial Cells of Cajal in Mouse Colon
by: Xingyou Huang, et al.
Published: (2024-04-01)

TrkA inhibition alleviates bladder overactivity in cyclophosphamide-induced cystitis by targeting hyperpolarization-activated cyclic nucleotide-gated channels
by: Qian Liu, et al.
Published: (2023-06-01)

cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4
by: Alessandro Porro, et al.
Published: (2020-07-01)

A Focus on Enterochromaffin Cells among the Enteroendocrine Cells: Localization, Morphology, and Role
by: Rita Rezzani, et al.
Published: (2022-03-01)

The cornucopia of intestinal chemosensory transduction
by: Paul P Bertrand
Published: (2009-12-01)

Enterochromaffin Cells and Mast Cells in Acute Appendicitis
by: Bhavya P. Mohan, et al.
Published: (2020-08-01)

The A328 V/E (rs2887147) polymorphisms in human tryptophan hydroxylase 2 compromise enzyme activity
by: Nurgul Carkaci-Salli, et al.
Published: (2023-09-01)

In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2
by: Alla B. Arefieva, et al.
Published: (2023-09-01)

Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish (<i>Danio rerio</i>)
by: Valentina S. Evsiukova, et al.
Published: (2021-11-01)

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2
by: Wendy K. Chung, et al.
Published: (2009-03-01)

Microscopic Interactions of Melatonin, Serotonin and Tryptophan with Zwitterionic Phospholipid Membranes
by: Jordi Martí, et al.
Published: (2021-03-01)

The Antidepressant-Like Effect of Lactate in an Animal Model of Menopausal Depression
by: Noof Abdullah Shaif, et al.
Published: (2018-11-01)

Propofol, an Anesthetic Agent, Inhibits HCN Channels through the Allosteric Modulation of the cAMP-Dependent Gating Mechanism
by: Morihiro Shimizu, et al.
Published: (2022-04-01)

Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population
by: Zheng Ping, et al.
Published: (2013-01-01)

Key indicators of serotonin synthesis in rat brain under chronic alcohol effect
by: V. V. Konopelnyuk, et al.
Published: (2013-04-01)

Structural Identification of the Pacemaker Cells and Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in the Heart of the Wild Atlantic Cod, <i>Gadus morhua</i> (Linnaeus, 1758)
by: Gioele Capillo, et al.
Published: (2021-07-01)

Cambios en la actividad y expresión de las triptófano-5-hidroxilasas cerebrales y en el número de neuronas serotoninérgicas por la diabetes mellitus, que no retornan a la normalidad con la insulina
by: Gabriel Manjarrez-Gutiérrez, et al.
Published: (2022-10-01)

Xenon’s Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice
by: Nour El Dine Kassab, et al.
Published: (2023-05-01)