The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review

The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review

Background: Carcinomas of unknown primary (CUP) account for 3–5% of all malignancy and, despite a reduction in incidence, the overall survival has not improved over the last decade. Chemotherapy regimens have not provided encouraging results. New diagnostic technologies, such as next generation sequ...

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Bibliographic Details
Main Authors: Roberta Lombardo, Federica Tosi, Annunziata Nocerino, Katia Bencardino, Valentina Gambi, Riccardo Ricotta, Francesco Spina, Salvatore Siena, Andrea Sartore-Bianchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
cancer of unknown primary (CUP)
next generation sequencing (NGS)
genomic alterations
comprehensive genomic profiling
targeted therapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00533/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00533/full

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