Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model.

Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model.

<h4>Background</h4>The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, di...

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Bibliographic Details
Main Authors: Melania Kurdián, Inmaculada Herrero-Fresneda, Nuria Lloberas, Pepita Gimenez-Bonafe, Virginia Coria, María T Grande, José Boggia, Leonel Malacrida, Joan Torras, Miguel A Arévalo, Francisco González-Martínez, José M López-Novoa, Josep Grinyó, Oscar Noboa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22427849/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22427849/?tool=EBI

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