INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

Summary: The genetic associations of TREM2 loss-of-function variants with Alzheimer disease (AD) indicate the protective roles of microglia in AD pathogenesis. Functional deficiencies of TREM2 disrupt microglial clustering around amyloid β (Aβ) plaques, impair their transcriptional response to Aβ, a...

Full description

Bibliographic Details
Main Authors: Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C. Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Molecular neuroscience
Immunology
Immune system
Immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223004522

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223004522

Similar Items