High-throughput screening identifies Aurora kinase B as a critical therapeutic target for Merkel cell carcinoma

High-throughput screening identifies Aurora kinase B as a critical therapeutic target for Merkel cell carcinoma

Abstract Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. Most MCCs contain Merkel cell polyomavirus (virus-positive MCC; VP-MCC), and the remaining are virus-negative (VN-MCC). Immune checkpoint inhibitors are the first-line treatment for metastatic MCC, but durable responses are achi...

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Bibliographic Details
Main Authors: Tara Gelb, Khalid A. Garman, Daniel Urban, Amy Coxon, Berkley Gryder, Natasha T. Hill, Lingling Miao, Tobie Lee, Olivia Lee, Sirisha Chakka, John Braisted, Jordan E. Jarvis, Rachael Glavin, Trisha S. Raj, Ying Xiao, Simone Difilippantonio, Amy Q. Wang, Min Shen, Ken Chih-Chien Cheng, Madhu Lal-Nag, Matthew D. Hall, Isaac Brownell
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56504-7

Internet

https://doi.org/10.1038/s41467-025-56504-7

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