SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc

SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc

Disruption of the blood-spinal cord barrier (BSCB) leads to inflammatory cell infiltration and neural cell death, thus, contributing to poor functional recovery after spinal cord injury (SCI). Previous studies have suggested that Sirtuin 1 (SIRT1), an NAD+-dependent class III histone deacetylase, is...

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Bibliographic Details
Main Authors: Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Redox Biology
Subjects:
Blood-spinal cord barrier
Spinal cord injury
SIRT1
p66Shc
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000162

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http://www.sciencedirect.com/science/article/pii/S2213231723000162

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