Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation

Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation

Abstract Osteoblasts play an important role in the regulation of bone homeostasis throughout life. Thus, the damage of osteoblasts can lead to serious skeletal diseases, highlighting the urgent need for novel pharmacological targets. This study introduces chemical genetics strategy by using small mo...

Full description

Bibliographic Details
Main Authors: Zhuo Yang, Xiao‐Wen Zhang, Fang‐Fang Zhuo, Ting‐Ting Liu, Qian‐Wei Luo, Yong‐Zhe Zheng, Ling Li, Heng Yang, Yi‐Chi Zhang, Yan‐Hang Wang, Dan Liu, Peng‐Fei Tu, Ke‐Wu Zeng
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Advanced Science
Subjects:
allosteric activation
forskolin
mitochondria
osteoblast differentiation
transglutaminase 2
Online Access:https://doi.org/10.1002/advs.202206533

Internet

https://doi.org/10.1002/advs.202206533

Similar Items