Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

Abstract Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual inhibition of these pathways by phytobiological compound c28MS has the potential of synergistic therapy for arthrit...

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Bibliographic Details
Main Authors: Shanzay Ahmed, Christopher B. Mahony, Alyssa Torres, Jessica Murillo-Saich, Samuel Kemble, Martha Cedeno, Peter John, Attya Bhatti, Adam P. Croft, Monica Guma
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Fibroblast-like synoviocytes
Glucose metabolism
Glutamine metabolism hexokinase
Glutaminase
Online Access:https://doi.org/10.1186/s13075-023-03161-0

Internet

https://doi.org/10.1186/s13075-023-03161-0

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