IQSEC2 Deficiency Results in Abnormal Social Behaviors Relevant to Autism by Affecting Functions of Neural Circuits in the Medial Prefrontal Cortex

IQSEC2 Deficiency Results in Abnormal Social Behaviors Relevant to Autism by Affecting Functions of Neural Circuits in the Medial Prefrontal Cortex

IQSEC2 is a guanine nucleotide exchange factor (GEF) for ADP-ribosylation factor 6 (Arf6), of which protein is exclusively localized to the postsynaptic density of the excitatory synapse. Human genome studies have revealed that the IQSEC2 gene is associated with X-linked neurodevelopmental disorders...

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Bibliographic Details
Main Authors: Anuradha Mehta, Yoshinori Shirai, Emi Kouyama-Suzuki, Mengyun Zhou, Takahiro Yoshizawa, Toru Yanagawa, Takuma Mori, Katsuhiko Tabuchi
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
IQSEC2
medial prefrontal cortex (mPFC)
social behavior
autism
synapse
Online Access:https://www.mdpi.com/2073-4409/10/10/2724

Internet

https://www.mdpi.com/2073-4409/10/10/2724

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