Synthesis, crystal structure, hirshfeld surface analysis, molecular docking and molecular dynamics studies of novel olanzapinium 2,5-dihydroxybenzoate as potential and active antipsychotic compound

Synthesis, crystal structure, hirshfeld surface analysis, molecular docking and molecular dynamics studies of novel olanzapinium 2,5-dihydroxybenzoate as potential and active antipsychotic compound

The antipsychotic drug Olanzapine was crystallized with aromatic acid, 2,5-dihydroxybenzoic acid in isopropyl alcohol by slow evaporation which led to the formation of olanzapinium 2,5-dihydroxybenzoate crystalline salt. The structure of the compound was characterized by 1H-NMR, 13C-NMR, and single-...

Full description

Bibliographic Details
Main Authors: V. Natchimuthu, Mohnad Abdalla, Manasi Yadav, Ishita Chopra, Anushka Bhrdwaj, Khushboo Sharma, S. Ravi, Krishnan Ravikumar, Khalid J. Alzahrani, Tajamul Hussain, Anuraj Nayarisseri
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Experimental Nanoscience
Subjects:
Olanzapinium 2,5-dihydroxybenzoate
X-ray structures
Co-crystal
Hirshfeld surface
molecular docking
molecular dynamics simulation
Online Access:https://www.tandfonline.com/doi/10.1080/17458080.2022.2063278

Internet

https://www.tandfonline.com/doi/10.1080/17458080.2022.2063278

Similar Items