Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences.

Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences.

CD8+ T cells are important for HIV-1 virus control, but are also a major contributing factor that drives HIV-1 virus sequence evolution. Although HIV-1 cytotoxic T cell (CTL) escape mutations are a common aspect during HIV-1 infection, less is known about the importance of T cell pressure in reversi...

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Bibliographic Details
Main Authors: Emily M Eriksson, Teri Liegler, Chris E Keh, Annika C Karlsson, Sara J Holditch, Christopher D Pilcher, Lisa Loeb, Douglas F Nixon, Frederick M Hecht
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4412704?pdf=render

Internet

http://europepmc.org/articles/PMC4412704?pdf=render

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