Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

Abstract Background Ovarian cancer is the second most common gynaecologic malignancy and the most common cause of death from gynaecologic cancer, especially due to diagnosis at an advanced stage, when a cure is rare. As ovarian tumour grows, cancer cells are exposed to regions of hypoxia. Hypoxia is...

Full description

Bibliographic Details
Main Authors: Sofia C. Nunes, Filipa Lopes-Coelho, Sofia Gouveia-Fernandes, Cristiano Ramos, Sofia A. Pereira, Jacinta Serpa
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Evolutionary Biology
Subjects:
Metabolic selection
Evolutionary trade-off
Ovarian cancer
Cysteine
Hypoxia
Chemoresistance
Online Access:http://link.springer.com/article/10.1186/s12862-018-1214-1

Internet

http://link.springer.com/article/10.1186/s12862-018-1214-1

Similar Items