DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma

DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma

Fibrolamellar carcinoma (FLC) is a rare liver cancer that affects adolescents and young adults. Genomic analysis of FLC has revealed a 400 kb deletion in chromosome 19 that leads to the chimeric transcript DNAJB1-PRKACA (DnaJ-PKAc), comprised of the first exon of heat shock protein 40 (DNAJB1) and e...

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Bibliographic Details
Main Authors: Sofia de Oliveira, Ruth A. Houseright, Benjamin G. Korte, Anna Huttenlocher
Format: Article
Language:English
Published: The Company of Biologists 2020-04-01
Series:Disease Models & Mechanisms
Subjects:
fibrolamellar carcinoma
liver
inflammation
early progression
non-invasive imaging
Online Access:http://dmm.biologists.org/content/13/4/dmm042564

Internet

http://dmm.biologists.org/content/13/4/dmm042564

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