Mechano Growth Factor Accelerates ACL Repair and Improves Cell Mobility of Mechanically Injured Human ACL Fibroblasts by Targeting Rac1-PAK1/2 and RhoA-ROCK1 Pathways

Mechano Growth Factor Accelerates ACL Repair and Improves Cell Mobility of Mechanically Injured Human ACL Fibroblasts by Targeting Rac1-PAK1/2 and RhoA-ROCK1 Pathways

Exceeded mechanical stress leads to a sublethal injury to anterior cruciate ligament (ACL) fibroblasts, and it will hinder cell mobility and ACL regeneration, and even induce osteoarthritis. The mechano growth factor (MGF) could be responsible for mechanical stress and weakening its negative effects...

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Bibliographic Details
Main Authors: Yongqiang Sha, Beibei Zhang, Liping Chen, Huhai Hong, Qingjia Chi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
mechano growth factor
anterior cruciate ligament
cell migration
cell adhesion
fracture strength
Online Access:https://www.mdpi.com/1422-0067/23/8/4331

Internet

https://www.mdpi.com/1422-0067/23/8/4331

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