Specificity of Interaction between Clostridium perfringens Enterotoxin and Claudin-Family Tight Junction Proteins

Clostridium perfringens enterotoxin (CPE), a major cause of food poisoning, forms physical pores in the plasma membrane of intestinal epithelial cells. The ability of CPE to recognize the epithelium is due to the C-terminal binding domain, which binds to a specific motif on the second extracellular...

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Bibliographic Details
Main Authors: Leslie A. Mitchell, Michael Koval
Format: Article
Language:English
Published: MDPI AG 2010-06-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/2/7/1595/