GPX8 regulates clear cell renal cell carcinoma tumorigenesis through promoting lipogenesis by NNMT

GPX8 regulates clear cell renal cell carcinoma tumorigenesis through promoting lipogenesis by NNMT

Abstract Background Clear cell renal cell carcinoma (ccRCC), with its hallmark phenotype of high cytosolic lipid content, is considered a metabolic cancer. Despite the implication of this lipid-rich phenotype in ccRCC tumorigenesis, the roles and regulators of de novo lipid synthesis (DNL) in ccRCC...

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Bibliographic Details
Main Authors: Tin Tin Manh Nguyen, Thi Ha Nguyen, Han Sun Kim, Thien T. P. Dao, Yechan Moon, Munjun Seo, Sunmi Kang, Van-Hieu Mai, Yong Jin An, Cho-Rok Jung, Jin-Mo Kim, Sunghyouk Park
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Clear cell renal cell carcinoma (ccRCC)
GPX8
NNMT
AMPK
De novo lipogenesis (DNL)
Online Access:https://doi.org/10.1186/s13046-023-02607-2

Internet

https://doi.org/10.1186/s13046-023-02607-2

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