The multifaceted mechanism of Leptin signaling within tumor microenvironment in driving breast cancer growth and progression.

The multifaceted mechanism of Leptin signaling within tumor microenvironment in driving breast cancer growth and progression.

Adipokines represent likely candidates to mediate the increased breast cancer risk and the enhanced progression associated with obesity. Other contributors to obesity-related cancer progression are insulin/IGF-1 pathways and hormones. Among these, the adipokine leptin is the most intensively studied...

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Bibliographic Details
Main Authors: Sebastiano eAndò, Ines eBarone, Cinzia eGiordano, Daniela eBonofiglio, Stefania eCatalano
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Oncology
Subjects:
Stem Cells
Tumor Microenvironment
breast cancer
estrogen receptor
leptin signaling
EMT transition
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00340/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00340/full

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