Calcium Binding Protein Ncs1 Is Calcineurin Regulated in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> and Essential for Cell Division and Virulence

Calcium Binding Protein Ncs1 Is Calcineurin Regulated in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> and Essential for Cell Division and Virulence

ABSTRACT Intracellular calcium (Ca2+) is crucial for signal transduction in Cryptococcus neoformans, the major cause of fatal fungal meningitis. The calcineurin pathway is the only Ca2+-requiring signaling cascade implicated in cryptococcal stress adaptation and virulence, with Ca2+ binding mediated...

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Bibliographic Details
Main Authors: Eamim Daidrê Squizani, Júlia Catarina Vieira Reuwsaat, Sophie Lev, Heryk Motta, Julia Sperotto, Keren Kaufman-Francis, Desmarini Desmarini, Marilene Henning Vainstein, Charley Christian Staats, Julianne T. Djordjevic, Lívia Kmetzsch
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mSphere
Subjects:
calcium binding protein
calcium sensor
Cryptococcus neoformans
calcium signaling
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00761-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00761-20

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