Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations: Implications for understanding its catalytic cycle

Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations: Implications for understanding its catalytic cycle

Type IIA DNA topoisomerases are complex molecular nanomachines that manage topological states of the DNA molecule in the cell and play a crucial role in cellular processes such as cell division and transcription. They are also established targets of cancer chemotherapy. Starting from the available c...

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Bibliographic Details
Main Authors: Matic Pavlin, Barbara Herlah, Katja Valjavec, Andrej Perdih
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Type IIA DNA topoisomerase
Catalytic cycle
Molecular simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023002593

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http://www.sciencedirect.com/science/article/pii/S2001037023002593

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