Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease.

Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease.

Chagas disease (CD) is caused by Trypanosoma cruzi, whose sugar moieties are recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that activates the lectin pathway of complement. MBL levels and protein activity are affected by polymorphisms in the MBL2 gene. We sequenced...

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Bibliographic Details
Main Authors: Paola Rosa Luz, Márcia I Miyazaki, Nelson Chiminacio Neto, Marcela C Padeski, Ana Cláudia M Barros, Angelica B W Boldt, Iara J Messias-Reason
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4706301?pdf=render

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http://europepmc.org/articles/PMC4706301?pdf=render

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