Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia

Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia

Abstract Resistance to regulated cell death is one of the hallmarks of human cancers; it maintains cell survival and significantly limits the effectiveness of conventional drug therapy. Leukemia represents a class of hematologic malignancies that is characterized by dysregulation of cell death pathw...

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Bibliographic Details
Main Authors: Xianbo Huang, Feng Xiao, Yuan Li, Wenbin Qian, Wei Ding, Xiujin Ye
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Necroptosis
Leukemia
Apoptosis resistance
RIPK1
RIPK3
MLKL
Online Access:http://link.springer.com/article/10.1186/s13046-018-0976-z

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http://link.springer.com/article/10.1186/s13046-018-0976-z

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