Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease
Two patients with X-linked chronic granulomatous disease without NAPDH oxidase activity and with high responses of flow-mediated vasodilation are reported. Bone marrow transplantation restored oxidative stress to the levels of those in healthy subjects and decreased flow-mediated vasodilation to the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-08-01
|
| Series: | JACC: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666084920306823 |
| _version_ | 1818600558003486720 |
|---|---|
| author | Yukihito Higashi, MD, PhD Shinji Kishimoto, MD, PhD Tatsuya Maruhashi, MD, PhD |
| author_facet | Yukihito Higashi, MD, PhD Shinji Kishimoto, MD, PhD Tatsuya Maruhashi, MD, PhD |
| author_sort | Yukihito Higashi, MD, PhD |
| collection | DOAJ |
| description | Two patients with X-linked chronic granulomatous disease without NAPDH oxidase activity and with high responses of flow-mediated vasodilation are reported. Bone marrow transplantation restored oxidative stress to the levels of those in healthy subjects and decreased flow-mediated vasodilation to the levels of those in healthy subjects in both of the patients. (Level of Difficulty: Advanced.) |
| first_indexed | 2024-12-16T12:37:23Z |
| format | Article |
| id | doaj.art-af5e1c3ecded4fa099321a3941a2b553 |
| institution | Directory Open Access Journal |
| issn | 2666-0849 |
| language | English |
| last_indexed | 2024-12-16T12:37:23Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Case Reports |
| spelling | doaj.art-af5e1c3ecded4fa099321a3941a2b5532022-12-21T22:31:31ZengElsevierJACC: Case Reports2666-08492020-08-0121014801483Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous DiseaseYukihito Higashi, MD, PhD0Shinji Kishimoto, MD, PhD1Tatsuya Maruhashi, MD, PhD2Address for correspondence: Prof. Yukihito Higashi, Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.; Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, JapanDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, JapanDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, JapanTwo patients with X-linked chronic granulomatous disease without NAPDH oxidase activity and with high responses of flow-mediated vasodilation are reported. Bone marrow transplantation restored oxidative stress to the levels of those in healthy subjects and decreased flow-mediated vasodilation to the levels of those in healthy subjects in both of the patients. (Level of Difficulty: Advanced.)http://www.sciencedirect.com/science/article/pii/S2666084920306823chronic granulomatous diseaseendothelial functiongp91phoxNADPH oxidasenitric oxideoxidative stress |
| spellingShingle | Yukihito Higashi, MD, PhD Shinji Kishimoto, MD, PhD Tatsuya Maruhashi, MD, PhD Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease JACC: Case Reports chronic granulomatous disease endothelial function gp91phox NADPH oxidase nitric oxide oxidative stress |
| title | Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease |
| title_full | Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease |
| title_fullStr | Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease |
| title_full_unstemmed | Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease |
| title_short | Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease |
| title_sort | endothelial function and oxidative stress in x linked gp91phox deficiency chronic granulomatous disease |
| topic | chronic granulomatous disease endothelial function gp91phox NADPH oxidase nitric oxide oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2666084920306823 |
| work_keys_str_mv | AT yukihitohigashimdphd endothelialfunctionandoxidativestressinxlinkedgp91phoxdeficiencychronicgranulomatousdisease AT shinjikishimotomdphd endothelialfunctionandoxidativestressinxlinkedgp91phoxdeficiencychronicgranulomatousdisease AT tatsuyamaruhashimdphd endothelialfunctionandoxidativestressinxlinkedgp91phoxdeficiencychronicgranulomatousdisease |