PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI

PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI

Abstract Chronic neuroinflammation and microglial activation are key mediators of the secondary injury cascades and cognitive impairment that follow exposure to repetitive mild traumatic brain injury (r-mTBI). Peroxisome proliferator-activated receptor-γ (PPARγ) is expressed on microglia and brain r...

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Bibliographic Details
Main Authors: Andrew Pearson, Milica Koprivica, Max Eisenbaum, Camila Ortiz, Mackenzie Browning, Tessa Vincennie, Cooper Tinsley, Michael Mullan, Fiona Crawford, Joseph Ojo
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-024-03173-w

Internet

https://doi.org/10.1186/s12974-024-03173-w

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