Presence of V72I, G123S and R127K Integrase Inhibitor polymorphisms could reduce ART effectiveness: a retrospective longitudinal study

Presence of V72I, G123S and R127K Integrase Inhibitor polymorphisms could reduce ART effectiveness: a retrospective longitudinal study

Objectives: Structural aspects of HIV-1 integrase complex and role of integrase minor mutations and polymorphisms in ART effectiveness is still unknown. The objective of this study was to assess the 24 and 48 weeks (W) effectiveness of ART regimens in patients with Integrase Inhibitors (InSTI) minor...

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Bibliographic Details
Main Authors: Anna Celotti, Franco Gargiulo, Eugenia Quiros-Roldan, Martina Properzi, Maria Antonia De Francesco, Davide Coletto, Francesca Caccuri, Ilaria Izzo, Arnaldo Caruso, Francesco Castelli, Emanuele Focà
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:HIV Research & Clinical Practice
Subjects:
integrase inhibitors (insti)
resistance associated mutations (rams)
polymorphisms
insti effectiveness
art
hiv resistance
Online Access:http://dx.doi.org/10.1080/25787489.2020.1734753

Internet

http://dx.doi.org/10.1080/25787489.2020.1734753

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