MRSamePopTest: introducing a simple falsification test for the two-sample mendelian randomisation ‘same population’ assumption

Abstract Two-sample MR is an increasingly popular method for strengthening causal inference in epidemiological studies. For the effect estimates to be meaningful, variant-exposure and variant-outcome associations must come from comparable populations. A recent systematic review of two-sample MR stud...

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Bibliographic Details
Main Authors: Benjamin Woolf, Amy Mason, Loukas Zagkos, Hannah Sallis, Marcus R. Munafò, Dipender Gill
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Research Notes
Subjects:
Online Access:https://doi.org/10.1186/s13104-024-06684-0