Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans

Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans

Aims: Mitochondrial dysfunction is implicated in several diseases, including neurological disorders such as Parkinson’s disease. However, there is uncertainty about which of the many mechanisms by which mitochondrial function can be disrupted may lead to neurodegeneration. Pentachlorophenol (PCP) is...

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Bibliographic Details
Main Authors: Zachary R. Markovich, Jessica H. Hartman, Ian T. Ryde, Kathleen A. Hershberger, Abigail S. Joyce, Patrick L. Ferguson, Joel N. Meyer
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Toxicology
Subjects:
Mitochondrial uncoupling
Dopaminergic neurodegeneration
Adverse outcome pathway
Redox tone
Caenorhabditis elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X22000214

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http://www.sciencedirect.com/science/article/pii/S2666027X22000214

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