Naïve CD8+ T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8+ T-Cells

Naïve CD8+ T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8+ T-Cells

Background: Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8+ T-cells from naïve precursors is essential for our understanding of adaptive immune responses and the development of immunotherapies. However, the metaboli...

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Bibliographic Details
Main Authors: Francesco Nicoli, Laura Papagno, Justin J. Frere, Mariela Pires Cabral-Piccin, Emmanuel Clave, Emma Gostick, Antoine Toubert, David A. Price, Antonella Caputo, Victor Appay
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
immunometabolism
mTOR
naïve T-cells
priming
CD8+ T-lymphocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02736/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02736/full

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